The key difference between L-serine and phosphatidylserine is that L-serine is a nonessential amino acid which is essential for the synthesis of phosphatidylserine while phosphatidylserine is a phospholipid and a component of the cell membrane.
L-serine and phosphatidylserine are two important chemical substances found in our body. L-serine is a nonessential amino acid which is produced in our body and a naturally occurring dietary amino acid. Phosphatidylserine, on the other hand, is a phospholipid, which is a main component in biological membranes. L-serine is essential for the synthesis of phosphatidylserine.