The key difference between sonication and homogenization is that sonication is a cell disruption technique which uses sound energy to disrupt tissues and cells, while homogenization is a cell disruption technique that mainly utilizes a physical force to break cell membranes.
In order to analyze biomolecules, their reactions and other cell contents, it is required to disrupt tissues to release cells and disrupt cells to release their contents. There are different cell lysis techniques. Sonication and homogenization are two such techniques. Sonication utilizes sound energy or ultrasonic waves to disrupt cells while homogenization utilizes mechanical force to disrupt cells.
