The key difference between Prevnar 13 and PPSV23 is that Prevnar 13 is a 13-valent pneumococcal conjugate vaccine while PPSV23 is a 23-valent pneumococcal polysaccharide vaccine.
Pneumococcal disease is a disease caused by the bacterium Streptococcus pneumoniae or pneumococcus. Generally, this bacterium causes various diseases ranging from serious diseases such as septicaemia, meningitis, and pneumonia to milder infections such as otitis media and sinusitis. However, pneumococcal diseases can be prevented by vaccines. There are two types of vaccines available to prevent pneumococcal pneumonia and its complications. They are Prevnar 13 and Pneumovax 23. These two differ from each other by way of administration and the types of bacteria they protect against.