The key difference between conidiophore and sporangiophore is that conidiophore is the aerial hypha of ascomycetes fungi that bears asexual spores called conidia while sporangiophore is the aerial hypha of zygomycetes fungi that bears asexual spores called sporangiospores.
Fungi are eukaryotic microorganisms which are filamentous in nature. They reproduce sexually as well as asexually. Asexual reproduction is mainly done by asexual spores. There are two main types of asexual spores; they are the conidia and sporangiospores. Conidia are produced in conidiophores. These conidiophores are special spore-bearing reproductive hyphae of Ascomycetes and Basidiomycetes. Meanwhile, sporangiospores are produced in sporangiophores. These sporangiophores are special spore-bearing reproductive hyphae of zygomycetes. Both conidiophores and sporangiophore produce spores through mitotic cell division. Moreover, both types of hyphae are aerial hyphae.