The key difference between membrane filtration and direct inoculation is that membrane filtration is a sterility testing that requires the test sample to first pass through a standard membrane that is capable of retaining microorganisms while direct inoculation is a sterility testing that requires the direct inoculation of test articles into tubes or bottles that contain an appropriate medium.
There are different types of safety tests, including sterility test, toxicity test and bacterial endotoxin test. Sterility test is done in order to assess whether the pharmaceutical product is free from contaminations or microorganisms. Therefore, it is a requirement for sterile pharmaceuticals, medical devices and materials to ensure they are safe for use. Membrane filtration and direct inoculation are two types of sterility tests.
