The key difference between histopathology and cytology is that histopathology is the study of diseased tissues using a microscope while cytology is the study of individual cells of the body.
Cells are the basic structural units of life. During the diagnosis of diseases in medicine, cells and whole tissues are examined by pathologists. The study of tissues in relation to disease is known as histopathology. In contrast, the study of a single cell type is known as cytology. Therefore, histopathology looks at tissues while cytology looks at individual cells.