The key difference between reductase and oxidoreductase is that reductase is an enzyme that catalyzes a reduction reaction, while oxidoreductase is an enzyme that catalyzes both oxidation and reduction reactions.
Redox reactions include both reduction and oxidation. During redox reactions, the oxidation states of the molecules or atoms are changed. Enzymes catalyze redox reactions. Oxidoreductase and reductase are two types of enzymes involved in redox reactions. Reductases catalyze reduction reactions (gaining of electrons) while oxidoreductases catalyze both oxidation (release of electrons) and reduction reactions (gaining of electrons).